Blar i forfatter "Hansen, Synne Simonsen"

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    • Myocardial metabolic, structural and functional remodelling following nutritional and hormonal stress 

      Hansen, Synne Simonsen (Doctoral thesis; Doktorgradsavhandling, 2022-06-22)
      The overall aim of this thesis was to increase our knowledge related to the underlying mechanisms of diabetes-induced cardiomyopathy. The primary objective of the first two papers was to elucidate the role of the reactive oxygen species (ROS) producing enzyme, NADPH oxidase 2 (NOX2), in the development of cardiac dysfunction in obesity/diabetes. We also wanted to examine the potential link between ...

    • Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise 

      Hancock, Matthew; Hafstad, Anne Dragøy; Nabeebaccus, Adam A.; Catibog, Norman; Logan, Angela; Smyrnias, Ioannis; Hansen, Synne Simonsen; Lanner, Johanna; Schröder, Katrin; Murphy, Michael P.; Shah, Ajay M.; Zhang, Min (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-27)
      Regular exercise has widespread health benefits. Fundamental to these beneficial effects is the ability of the heart to intermittently and substantially increase its performance without incurring damage, but the underlying homeostatic mechanisms are unclear. We identify the ROSgenerating NADPH oxidase-4 (Nox4) as an essential regulator of exercise performance in mice. Myocardial Nox4 levels ...

    • NADPH oxidase 2 mediates myocardial oxygen wasting in obesity 

      Hafstad, Anne Dragøy; Hansen, Synne Simonsen; Lund, Jim; Santos, Celio X.C.; Boardman, Neoma Tove; Shah, Ajay M.; Aasum, Ellen (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-19)
      Obesity and diabetes are independent risk factors for cardiovascular diseases, and they are associated with the development of a specific cardiomyopathy with elevated myocardial oxygen consumption (MVO<sub>2</sub>) and impaired cardiac efficiency. Although the pathophysiology of this cardiomyopathy is multifactorial and complex, reactive oxygen species (ROS) may play an important role. One of the ...

    • The role of NADPH oxidases in diabetic cardiomyopathy 

      Hansen, Synne Simonsen; Aasum, Ellen; Hafstad, Anne Dragøy (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-25)
      Systemic changes during diabetes such as high glucose, dyslipidemia, hormonal changes and low grade inflammation, are believed to induce structural and functional changes in the cardiomyocyte associated with the development of diabetic cardiomyopathy. One of the hallmarks of the diabetic heart is increased oxidative stress. NADPH-oxidases (NOXs) are important ROS-producing enzymes in the cardiomyocyte ...